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Response to the FDA's May 23, 2007, nephrogenic systemic fibrosis update. Radiology 2008; 246:11-14 [21] Donahue MJ, Blakeley JO, Zhou J, Pomper MG, Laterra J, van Zijl PC. Evaluation of human brain tumor heterogeneity using multiple T1-based MRI signal weighting approaches. Magn Reson Med 2008; 59:336-344 [22] Howe FA, Opstad KS. 1H MR spectroscopy of brain tumours and masses. NMR Biomed 2003; 16:123-131 [23] Castillo M, Kwock L, Mukherji SK. Clinical applications of proton MR spectroscopy. AJNR Am J Neuroradiol 1996; 17:1-15 [24] Nelson SJ.

Patient motion during image acquisition may introduce abnormal ‘bright’ or ‘dark’ areas in a normal brain that can even simulate a lesion. 6. Magnetic field inhomogeneity presents problems with spatial resolution. 4. Brain tumour imaging using gadolinium contrast agents The most common clinical application of CE-MR neuroimaging is in the evaluation of primary and secondary brain tumours. The goals of conventional brain tumour imaging are the sensitive detection and delineation of tumour to make a correct diagnosis and accurate tumour grading to facilitate appropriate intervention.

A diagnostic dilemma. Curr Oncol, Vol. 16, No. 1, (Jan), pp. E. Speca, M. Hagen, N. & Taenzer, P. (2001). Computerized quality-of-life screening in a cancer pain clinic. J Palliat Care, Vol. 17, No. 1, pp. 46-52 Cella, D. , J. (2002). Measuring quality of life in chronic illness: the functional assessment of chronic illness therapy measurement system. Arch Phys Med Rehabil, Vol. 83, No. 12 Suppl 2, pp. F. S. Gray, G. Sarafian, B. Linn, E. Bonomi, A. Silberman, M. B. Winicour, P. Brannon, J. & et al.

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