By Duane J. Gubler, Eng Eong Ooi, Subhash Vasudevan, Jeremy Farrar
Greater than 20,000 deaths are linked to dengue virus infections each year, and DF/DHF is without doubt one of the most vital rising tropical ailments on the planet. fresh intriguing examine on dengue viruses has ended in significant advances in our knowing of all features of the biology of dengue viruses. This up to date moment version brings jointly major examine and scientific scientists to check the newest findings on dengue virus biology, epidemiology, entomology, therapeutics, vaccinology and scientific administration.
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Additional resources for Dengue and Dengue Hemorrhagic Fever
Eitrem, R. and Niklasson, B. (1993) Dengue fever among Swedish tourists. Scandinavian Journal of Infectious Diseases 25, 699–704. P. , Pimgate, C. W. (2012) Underrecognized mildly symptomatic viremic dengue virus infections in rural Thai Schools and villages. Journal of Infectious Diseases 206, 389–398. A. (1999) Cuban allegations of biological warfare by the United States: assessing the evidence. Critical Reviews in Microbiology 25, 173–227. 2 Mapping the Epidemiology of Dengue Oliver J. Brady,1 Jane P.
1995). However, these results and conclusions are highly questionable for the following reasons: 1. The putative Cuban DENV-2 did not spread outside of Cuba, as this virus strain was never isolated in any other countries of the region. Guzmán et al. (1995) concluded that this geographic isolation was likely due to the strict quarantine system established by the Cuban government during the epidemic. 2. Several strains of a newly introduced DENV-2 were isolated from patients during an outbreak in Jamaica in early 1982 (Gubler, 1987b, 1993).
The case-fatality rate of DHF averages about 5%; WHO estimates more than 20,000 deaths each year (WHO, 2009). , 2013; Chapter 2, this volume). Factors Responsible for the Global Resurgence of Dengue Clearly, the declaration that the war on infectious diseases had been won in the late 1960s (Henderson, 1993) was a major factor in creating apathy and complacency about a disease like dengue that wasn’t considered a major public health problem in the first 19 place. This led to policy changes, a redirection of resources and decay in the public health infrastructure to deal with infectious disease in general and vector-borne diseases in particular (Gubler, 1989, 1998, 2001, 2011; Gubler and Trent, 1994).