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Additional info for Criteria (Dose/Effect Relationships) for Organochlorine Pesticides. Report of a Working Group of Experts Prepared for the Commission of the European Communities, Directorate-General for Employment and Social Affairs, Health and Safety Directorate

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These doses represent about 1, 20 and 200 times the ordinary dietary level of DDT. During the studies, no subject complained of any sjrmptoms or showed, by the tests employed, any sign of illness that did not have an easi­ ly recognised cause clearly unrelated to exposure to DDT. At inter­ vals, the men were given a physical examination and a variety of laboratory tests. Particular attention was given to neurological examination and liver function tests. The storage of DDT in body fat was found to be proportional to dosage.

There was modification of the proteinogram, decrease of blood catalase and plasma Cholinesterase and disturbance of biliary excretion. The haematological changes showed a tendency towards hypochromic anaemia and leucopaenia. Several other reports have described the symptomatology of chronic HCH poisoning observed in workers. For exanple, in groups of workers using HCH,dermal and mucous membrane irritation, leucopaenia and anaemia have been observed (Bogonsevski and Burkatskaia, 1951). , 1969). The binding of lindane to plasma proteins has been demonstrated (free serum concentration between 1,3 and 1,5 % ) .

Over 30 cases of aplas­ tic anaemia associated with exposure to HCH or Lindane and 21 cases with exposure to HCH with DDT have been described (Storen, 1955 ; Join, 1963 ; Loge, 1965 ; McLean, 1966). A. Conmiittee on Pesticides, 1953 ; Mandeloff and Smith, 1955 ; Albahary, 1957). , 1958) and an increased incidence of leucopenia in a group of apple growers, following exposure to HCH have been described (Brown, 1967). , 1962). Two studies have been carried out on groups of 79 and 80 workers known to have been occupationally exposed to lindane for periods of seve­ ral weeks to several years.

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