By L. F. Bélanger, T. Semba, S. Tolnai, D. H. Copp, L. Krook, C. Gries (auth.), H. Fleisch, H. J. J. Blackwood, M. Owen (eds.)
The papers accumulated during this quantity characterize the formal court cases of the 3rd eu Symposium on Calcified Tissues which was once held in Davos, Switzerland from eleventh to sixteenth April 1965 lower than the sponsorship of the Laboratorium fur experi mentelle Chirurgie, Schweizerisches Forschungsinstitut Davos. This Symposium fol lowed the now tested culture of the former Symposia held in Oxford in 1963 and in Liege in 1964. Participation used to be back strictly on a residential hasis. This yr the Schatzalp lodge supplied a scenic and secluded assembly position excessive on a mountain aspect overlooking Davos but on the subject of the Forschungsinstitut during which the hole consultation of the Symposium was once held. The papers and communications released within the quantity are prepared so as of presentation and are grouped below the 5 major topics chosen for dialogue via the Symposium, particularly, "Cell functionality within the formation, upkeep and destruc tion of osseous tissue", "Response of calcified tissues to mechanical factors", "Mecha nisms of mineralization and ailments regarding mineral deposition", "Hormones and bone" and "Fundamental constitution of dental difficult tissues". The programme consisted of a few evaluation lectures given by way of invited audio system and of brief communications on the subject of all of the above issues. No test used to be made to checklist the dis cussions to the papers as, being a residential assembly, the extra important and curiosity ing interchanges came about informally in small chat groups and never in the time agenda of the prearranged programme.
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Additional info for Calcified Tissues 1965: Proceedings of the Third European Symposium on Calcified Tissues
This difference must change the relationship of the collagen framework with its surrounding medium. It surely has some side effect on the metabolism of the fibers. It is, however, too early to take this into consideration. In the present discussion we shall only consider the problem related to the synthesis and the breakdown of the matrix in calcified tissues. Composition and organization of the bone matrix The dry weight of bone is composed of 65-70% of inorganic crystals of calcium and phosphate and 30-350/o of an organic matrix in which the collagen accounts for as much as 90-95°/o (EASTOE, 1956).
Clearly at the moment this concept is, in our situation only a formalism, although HEKKELMAN and I are speculating that the non available fraction, if existing at ali, could be hidden in the nucleus of the cells. In relation to what I have said I would like to report furthermore an important observation made by (CoRN and GRIFFITH, 1965) working with slices of the distal ends of rabbit femora. They found NAD and NADP specifically capable of stimulating the C1402 evolution from Fumarate-1,4-C14 • Using Citrate-1,5-C 14 this effect failed to appear.
Exp. Med. 107, 247 (1958 a). Studies on the formation of collagen. II. The influence of growth rate on neutra! salt extracts of guinea pigs dermis. J. exp. Med. 107, 265 (1958 b). Studies on the formation of coilagen. III. Time-dependent solubility changes of collagen in vitro. J. exp. Med. 108, 215 (1958 c). On the significance of the soluble collagens. In Connective Tissue, Thrombosis and Atherosclerosis. PAGE, I. H. ). New York: Academic Press 1959, p. 77. An intermolecular defect of collagen in experimental lathyrism.