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By Kivie Moldave, Sankar Mitra, Amanda K. McCullough, R. Stephen Lloyd, Samuel H. Wilson (Eds.)

This quantity of growth in Nucleic Acid learn and Molecular Biology represents study mentioned through the DNA Base Excision fix Workshop. This compilation of articles specializes in a number of contemporary observations highlighting the complexity of the bottom excision fix (BER) approach in DNA fix. concentrating on many of the points of BER learn, this ebook is a well timed and hugely necessary reference for investigators within the DNA fix box. it's going to additionally reduction scientists in a roundabout way fascinated about fix reviews to procure a accomplished figuring out of the present nation of information within the box.

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G. Dianovand T. Lindahl, Curt Biol. 4, 1069-1076 (1994). 2. Kubota,R. Nash,A. Klungland, P. Schar, D. Barnes, and T. Lindahl,EMBOJ. 15, 6662~6670 (1996). 3. D. K, Srivastava,B. J. Vande, R. Prasad, J. T. Molina,W. A. Beard, A. E. Tomkinson, and S. H. Wilson,J. Biol. Chem. 273, 21203-21209 (1998). 4. A. Klungland, M. Hoss, D. Gunz, A. Constantinou, S. C. Clarkson, P. W. Doetsch, P. H. Boltin, R. D, Wood,and T. Lindahl, Mol. Cell 3, 1-20 (1999). 5. G. Dianov, C. Bischoff,J. Piotrowski,andV. A. Bohr,J.

G p Cm P"IP' p.?. _L p _ L p _ L p_JL p _ L p_JL p_L5, FIG. 1. (continued). A C 8 EUGENIA DOGLIOTTIET AL. : :),J 0 aldehyde j APsiteanalogsI s,\ s,\ O-~ OH O/H 0 z,_~ (F) (redAP) 0-~ OH OH 0 z,_/ (MXAP) FIG. 2. F, tetrahydrofuran;redAP, reduced AP site; MXAP,methoxyaminemodifiedAP site. (8-oxoG), which is excised by the mammalian bifunctional DNA glycosylase OGG1 (Fig. 1B) (5, 6). A third variation on the scheme (Fig. 1C) is the production of a gap that exceeds one nucleotide. This would be the consequence of a strand displacement reaction of the strand containing the dRP residue at the incised AP site.

E. Krokan, EMBO 1. 18, 3834~844 (1999). R. M. Taylor, D. J. Moore, J. Whitehouse, P. Johnson, and K. W. Caldecott, Mol. Cell. Biol. 20, 735-740 (2000). R. S. Tebbs, J. j. Meneses, R. A. Pedersen, L. H.

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