By Derek Kinchington, Raymond F. Schinazi
Skilled scientists describe-in an easily-followed format-their cutting-edge innovations for comparing antiviral compounds. The assays defined contain structures for investigating medicinal drugs used opposed to herpesviruses, hepatitis viruses, human immunodeficiency viruses, human papillomaviruses, and influenza viruses. those well-tested equipment diversity from mobile assays to a couple of the main up to date molecular techniques for making a choice on compounds which are lively opposed to viral enzymes and the advance of viral resistance opposed to medications presently in use. well timed and finished, Antiviral tools and Protocols bargains latest researchers in academia, medical departments, and the pharmaceutical the strong, reproducible, and novel equipment had to overview compounds powerful opposed to either acute and persistent infections.
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Additional resources for Antiviral Methods and Protocols (Methods in Molecular Medicine)
Accidental laboratory infection may cause serious infection but effective treatment and preventive measures are available. The risk of spread of infection is limited. · Hazard/Risk Group 3: A virus that may cause serious human disease and offers a special hazard to laboratory workers. It may present a risk of spread in the community but effective treatment and preventive measures are usually available. · Hazard/Risk Group 4: A virus that usually causes serious human disease and is extremely hazardous to laboratory workers.
Kinchington and R. F. 2 RhinovirusNasal drops 1 Venezuelan equine encephalitisSubcutaneous 1 West Nile feverIntramuscular 1 Poliovirus 1Ingestion 2 RubellaPharyngeal spray 10 Influenza A2Nasopharyngeal 790 aNumbers of cell culture infectious doses or animal infectious units. 1 Virus 1. Virulence may be defined as the ability of a virus to invade host tissues and cause disease. Table 2 shows the infectious doses of some viruses are very low (data taken from ref. 3). 2. Transmissibility: The risk of spread of infection will be determined by the probability of secondary and tertiary cases.
Procedures: The most commonly reported types of activities associated with laboratory-acquired infections are listed in Table 3. 3 Host 1. Exposure route: Outcome may be affected by route of infection; for example, blood-borne viruses do not readily cause infection by the respiratory route. 2. Individual host characteristics: Compromising factors that can influence the particular consequences of exposure to infection include immune status and pregnancy. 3. Presence in body fluids: An awareness should be maintained of both viral and other, nonviral pathogens that may be present in body fluids (blood, saliva, sputum, semen, and breast milk).