Download Amphioxus immunity : tracing the origins of human immunity by An-Long Xu PDF

By An-Long Xu

Amphioxus Immunity: Tracing the starting place of Human Immunity covers a amazing diversity of data approximately Amphioxus and its evolutionary context. This compilation of what's at present identified approximately Amphioxus, with a pointy concentrate on its immune approach, contains thirteen issues, such as:

  • Amphioxus as a version for realizing the evolution of vertebrates
  • basic wisdom of immunology
  • immune organs and cells of amphioxus
  • a genomic and transcriptomic view of the Amphioxus immunity
  • pattern attractiveness procedure in Amphioxus
  • transcription elements in Amphioxus
  • the supplement procedure of Amphioxus
  • the oxidative burst procedure in Amphioxus
  • immune effectors in Amphioxus
  • lipid signaling of immune reaction in Amphioxus
  • apoptosis in amphioxus; primitive adaptive immune approach of Amphioxus
  • and destiny learn directions

This useful reference ebook is loaded with info that would be priceless for a person who needs to profit extra in regards to the starting place of vertebrates and adaptive immunity.

  • Provides new proof at the foundation of the adaptive immune procedure, the evolution of innate immunity, and evolution-stage particular immune safeguard mechanisms
  • Not simply offers the cells and molecules focused on the adaptive immune reaction in Amphioxus, but in addition characterizes the origination and evolution of the gene households and pathways serious about innate immunity
  • Includes a lot pioneering paintings, from the molecular, genomic, and mobile to the person level

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Extra resources for Amphioxus immunity : tracing the origins of human immunity

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Signalling through C-type lectin receptors: shaping immune responses. Nat. Rev. Immunol. 9, 465–479. , 1988. The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52, 269–279. , 2010. Intestinal bacteria and the regulation of immune cell homeostasis. Annu. Rev. Immunol. 28, 623–667. , 2009. Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2. Glycobiology 19, 568–575. , 2006. 5’-Triphosphate RNA is the ligand for RIG-I.

In each gene family, C gene segments encode the constant regions. 9A. Based on the multigene segments of Ig, the gene arrangement produces the diversified antibody by the recombinases RAG1 and RAG2, which initiate the recombination by recognizing the recombination signal sequences (RSSs) flanking each germline V, D, and J gene segment. 9B. In addition, somatic hypermutation also adds to the generation of diversity in already rearranged gene segments. Similar to the mechanism of antibody diversity generation, TCR can produce tremendous diversity.

After the recognition of different ligands, inflammation and cell death are two major effects of the NLR-induced signaling pathway. Salmonella infection leads to caspase­1–dependent cell death, which is unique for its morphologic characteristics compared to classical apoptosis; this is termed pyroptosis. Pathogen-induced cell death causes the release of cellular contents that can in turn activate a stronger inflammatory response. This positive feedback loop is efficient to boost an amplified inflammatory response for the intruding pathogens or damaged molecules.

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