Download Advancing Prion Science: Guidance for the National Prion by Institute of Medicine, Medical Follow-Up Agency, Committee PDF

By Institute of Medicine, Medical Follow-Up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura B. Sivitz, Rick Erdtmann

Provides a record from the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies recommending learn to shut major gaps in current wisdom of prion ailments and methods for strengthening the U.S. learn infrastructure for learning those ailments. Softcover. DNLM: Prion ailments, prevention & control--United States.

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Additional info for Advancing Prion Science: Guidance for the National Prion Research Program

Sample text

This stymies the use of vaccines to prevent TSEs because vaccines work by exploiting the body’s natural immune response. , 2002). Treatment for Human TSEs Many therapeutic agents used to treat human TSEs have produced disappointing results (Brown, 2002). Treatment barriers include the inability to diagnose TSEs in early preclinical stages, the appearance of clinical signs only after advanced CNS infection, the failure of many agents to cross the blood–brain barrier, intrinsic toxicity associated with the therapeutic agents, and difficulties in translating promising therapeutic results from the research laboratory to the clinic.

Gambetti P. 2002. TSE Surveillance of Humans in the United States. Presentation to the IOM Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Meeting 1. Washington, DC: National Academy Press. S. General Accounting Office). 2002. S. Prevention Efforts. GAO-02-183. Washington, DC: GAO. Harvard Center for Risk Analysis and Tuskegee University Center for Computational Epidemiology. 2001. Evaluation of the Potential for Bovine Spongiform Encephalopathy in the United States.

The Need for Novel Approaches to Developing TSE Diagnostics Major improvements in TSE diagnostics must await the availability of novel testing techniques or of reagents designed to specifically target PrPSc. 3: Fund research to develop novel methods and reagents that detect or bind to prions, including new antibodies, peptides, nucleic acids, synthetic derivatives, and chimeric molecules. This research could lead not only to better diagnostics, but also to better therapeutic and prophylactic strategies.

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