By Leslie J. DeGroot (auth.), Barry B. Bercu, Dorothy I. Shulman (eds.)
Perinatal difficulties in thyroid gland body structure are universal yet complex and current a diagnostic hindrance for the first clinician. In December 1990, a world staff of easy and medical investigators amassed in Longboat Key, Florida to handle those concerns. The members incorporated internists, obstetricians, pedia tricians, neurologists, pathologists and easy scientists in mobile metabolism, endocrine body structure, and molecular biology. The displays contained inside this booklet collect their most present and important study concerning the sector of perinatal thyroidology. This ebook is predicated at the dynamic and fruitful alternate of the individuals on the symposium. we're indebted to those contributors whose priceless insights and efforts are contained inside this article. Barry B. Bercu Dorothy I. Shulman vii CONTENTS consultation I Mechanism of Thyroid Hormone motion 1 Leslie J. DeGroot Thyroid method Ontogeny within the Sheep: A version for Precocial Mammalian Species • . . • • eleven Delbert A. Fisher Pathologic reports of Fetal Thyroid 27 improvement • • • • • • • Douglas R. Shanklin Thyroid Hormone keep watch over of mind and Motor improvement: Molecular, Neuroanatomical, forty seven and Behavioral stories • • • • • • • S. A. Stein, P. M. Adams, D. R. Shanklin, G. A. Mihailoff, and M. B. Palnitkar The Thyroidectomized Pregnant Rat: An Animal version to check Fetal results of Maternal Hypothyroidism 107 Susan P. Porterfield and Chester E.
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Extra resources for Advances in Perinatal Thyroidology
J C1in Invest 79:295-300 (1987). 26 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. D. A. FISHER wu SY, Klein AH, Chopra IJ, Fisher DA. Alterations in tissue thyroxine 5'-monodeiodinating activity in the perinatal period. Endocrinology 103:235-239 (1978). Klein AH, Oddie TH, Fisher DA. Iodothyronine kinetic studies in the newborn lamb. J Devel Physiol 2:29-35 (1980). Fisher DA and Polk DH. , New York, pp 61-77 (1989). Ferreiro B, Bernal J, Potter BJ. Ontogenesis of thyroid hormone receptor in foetal lambs.
1989 Welner. : Cordocentesis. n~er. , S. Balzano. H. Scherberg and S. Reretoff: N2onata1 detection of generalized resistance to thyrold hormone. A. 264:2245-2250. D .. P. Weiner. A. S. Grant: Pr2natal diagnosis of f~tal hyperthyroidism using funl~unctur(. K. H. llctur'2 d "foamy" follicles in thyroid glands of C3H mice. prU2~~ 37:3932. 196E. K. H. Wollman: Fine structure oi a second klnd of thyroid foll1cle in the C3H mouse. Ql", 84: 563-578. A. M. R. A. B. Palnitkar1 IDepartment of Neurology and 2Department of Psychiatry University of Texas Southwestern Medical Center Dallas, Texas 3Departments of Pathology and Obstetrics and Gynecology University of Tennessee-Memphis Memphis.
At 31 weeks secondary gyration is advanced. Outer granulocytes are largely gone and the cortical mantle is almost completely formatted. Few migratory neural elements remain. Layering is recognizable, best defined in layer 3-4; layer 4 is not easily distinguished from 3. Pyramidal connectivity has developed in layer 5. Myelination is found in the internal capsule. Variation in development and maturation of cortex were shown by Marin-Padilla. 6 weeks, had a more mature layer 4, among other features.