Download Adenoviruses: Model and Vectors in Virus-Host Interactions: by M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, PDF

By M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, Petra Böhm (eds.)

After 3 volumes on adenoviruses in 1995 the prior years have visible speedy growth within the box of adenovirus examine. in addition, adenoviruses have attracted enormous curiosity as vectors in gene move regimens.

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Extra resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions

Example text

1996; FENDER et al. 1997). Like the native virus, these particles enter cells efficiently via the endocytotic pathway and accumulate at the nuclear membrane (FENDER et al. 1997; Fig. 2) which suggests that during their passage toward the nucleus they interact with adenovirus cellular partners. Both types of dodecahedra enter cells, with base dodecahedra entering less efficiently. This suggests that bases alone are able to attach to the plasma membrane, to interact with coated pits, to escape to cytoplasm and to attach to the nuclear membrane.

I Gen ViroI82:525-529 NAGY M, NAGY E, TUBOLY T (2002) Sequence analysis of porcine adenovirus serotype 5 fiber gene: evidence for recombination. Virus Genes 24:177-181 OGAWA M, AHNE W, ESSBAUER S (1992) Reptilian viruses: adenovirus-like agent isolated from royal python (Python regius). I Vet Med B 39:732-736 OJKIC D, NAGY E (2000) The complete nucleotide sequence of fowl adenovirus type 8. I Gen ViroI81:1833-1837 PAYET Y,ARNAULD C, PICAULT IP, IESTIN A, LANGLOIS P (1998) Transcriptional organization of the avian adenovirus CELO.

WWP3 belongs to the family of membrane-associated guanylate kinase homologs (MAGUK). These multidomain proteins act as molecular scaffolds for signaling pathway components at the plasma membrane of eukaryotic cells where they are involved in the formation of various types of cell junctions and maintenance of cell shape (DIMITRATOS et al. 1999). They function by binding to the cytoplasmic termini of membrane proteins, which results in bringing together different components of multi-molecular complexes and clustering them at the plasma membrane.

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