By Eric Topol
With special contributions from forty five popular foreign professionals, this 3rd version stands by myself because the such a lot accomplished, modern view of the biology, body structure, and administration of acute coronary syndromes (ACS)-offering 32 chapters that span the state-of-the technology within the box and supply fascinating discussions on CRP and different sickness markers, microcirculation, stem mobile remedy, and the advance of specialised facilities for ACS remedy.
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Additional resources for Acute Coronary Syndromes, Third Edition
Braunwald E. 4 substudy. J Am Col1 Cardiol 3998;31:1460-1465. Milazzo D, Biasucci LM, Luctani N, Marttnelli L, Canosa C, Schinvello R. Maseri A, Possati G. Elevated levels of C-reactive protein before coronary artery bypass grafting predict recurrence of ischemic events. A m J Cardiol 1999;84:459-46 I , A9. Liuzzo G. Buffon A. Biasucci LM. Gallimore JR. Caligiuri G, Vitelli A, Altatnura S, Ciliberto G, Rebuzzi AG, Crea F, Pepys MB, Maseri A. Enhanced inflammatory response t o coronary angioplasty in patients wtth severe unstable angina.
Gregory S, Olson G, Hauser S. Leahy K, Perkins W. Isakson P. Mediation of inflammation by cyclooxygcnase-2. Agents Actions Suppl l995;46:41 -50. 136. Baker CS. Hall RJ. Evans TJ, Pomcrance A. Maclouf J, Crctninon C, Yacouh MH, Polak JM. Cyclooxygenase-2 is widely expressed i n atherosclerotic lesions affecting native and transplanted human coronary arteries and colocal1zes with inducible nitric oxide synthase and nitrotyrosine particularly i n macrophages. Arterioscler Throtnb Vasc Biol 1999: 19:646-655.
Aspirin reduced first MI in the Physicians Health Study, and this effect was directly related to the baseline CRP level (144) (Fig. 1 l ) . In addition, the recent negative results of the oral ITb/IIIa receptor inhibitor may be explained in part by the lack of aspirin’santi-inflammatoryproperties in the group receiving sole oral Ilb/IIIa treatment. 1 7 n Death Major event Re MI Figure 1 1 Cardiovascularevents allocated tobackground of NSAID(solidbars) and control (opcn bars). Aparadigmshift in thought may be evolving in favor of theantiinflammatory properties of aspirin being more salient than its relatively weak antiplatelet effects in the reduction of ischemic cardiac events.