Download A Field Guide to Germs (Revised and Updated Edition) by Wayne Biddle PDF

By Wayne Biddle

From the ravages of the Ebola virus in Zaire to outbreaks of pneumonic plague in India and drug-resistant TB in big apple urban, contagious ailments are combating again opposed to once-unconquerable smooth medication. Public difficulty approximately infectious affliction is at the upward push as newspapers trumpet the arrivals of recent germs and the reemergence of outdated ones.

In A box advisor to Germs, Pulitzer Prize-winning technology author Wayne Biddle brings readers head to head with approximately 100 of the best-known (in phrases of incidence, strength, old significance, or perhaps literary curiosity) of the myriad pathogens that reside in and round the human inhabitants. in addition to actual descriptions of the organisms and the afflictions they reason, the writer presents folklore, philosophy, heritage, and such illustrations as 19th century drawings of plague-induced panic, microscopic pictures of HIV and Ebola, and wartime posters caution servicemen opposed to syphilis and gonorrhea.

From cholera to chlamydia, TB to HIV, bubonic plague to Lyme illness, rabies to Congo-Crimean encephalitis, anthrax to Zika fever, and again to sturdy outdated rhinitis (the universal cold), A box consultant to Germs is either a convenient reference paintings to raised comprehend today's headlines and a desirable examine the striking influence of micro-organisms on social and political history.

Winner of the yankee scientific Writers Association's Walter C. Alvarez Honor Award.

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Extra resources for A Field Guide to Germs (Revised and Updated Edition)

Sample text

These families of molecules are shared with other leukocytes and are distinguished by their structure. The major families include: • the immunoglobulin superfamily; • the integrin family; • selectins; • proteoglycans. The immunoglobulin superfamily comprises molecules with structural characteristics similar to those of the CHAPTER Lymphocytes 2 Morphological heterogeneity of lymphocytes M GA PL 1 3 2 Fig. 19 Lymphocyte morphology. (1) The small lymphocyte has no granules, a round nucleus, and a high N:C ratio.

NKT cells are therefore thought to act as an interface between the innate and adaptive systems by initiating T cell responses to non-peptide antigens. g. IL-10). B cells recognize antigen using the B cell receptor complex About 5–15% of the circulating lymphoid pool are B cells, which are defined by the presence of surface immunoglobulin, transmembrane molecules, which are constitutively produced and inserted into the B cell membrane, where they act as specific antigen receptors. Most human B cells in peripheral blood express two immunoglobulin isotypes on their surface: • IgM; and • IgD (see Chapter 3).

16). They participate in two important stages in T cell maturation/differentiation in thymus positive and negative selection respectively (see below). FDCs lack class II MHC molecules and are found in B cell areas Unlike the APCs that actively process and present protein antigens to T cells, FDCs have a passive role in presenting antigen in the form of immune complexes to B cells. They are therefore found in the primary and secondary follicles of the B cell areas of the lymph nodes, spleen, and MALT (see Fig.

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