By Pierre Hainaut, Klas G. Wiman
P53 has emerged as a key tumor suppressor and critical goal for novel melanoma treatment. This e-book, written by means of world-leading p53 researchers together with lots of those that have formed the sphere during the last 25 years, presents special insights into the growth of the sphere and the customers for larger melanoma analysis and remedy sooner or later.
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Extra info for 25 Years of P53 Research
G. ), 25 Years of p53 Research, 27-51. © 2005 Springer. Printed in the Netherlands. 28 Chapter 2 R248 R273 R175 G245 R249 AD1 1 20 AD2 40 R282 PXXP 60 TETRA 90 97 100 300 320 360 363 393 Figure 1. fr/p53). Indicated are the N-terminal activation domains (AD1, AD2), the proline rich region (PXXP), the central core sequence specific DNA binding domain (DNA BINDING CORE), the tetramerization domain (TETRA) and the C-terminal sequence non-specific nucleic acid binding region (BASIC). TRANSACTIVATION DOMAIN The first 100 amino acids of p53 contain two transactivation domains, a proline-rich domain and a nuclear export signal.
Genes and Development, 1993. 7: 1126-1132. , Beach D. p21 is a universal inhibitor of cyclin kinases. Nature, 1993. 366: 701-704. , Experimental study off the pathogenesis of carcinoma. Journal of Cancer Research, 1918. 3: 1-29. , Rannala B, Likelihood models of somatic mutation and codon substitution in cancer genes. Genetics, 2003. 165: 695-705. , Oren M. Sequence-specific DNA binding by p53: identification of target sites and lack k of binding to p53-MDM2 complexes. EMBO J, 1993. 12: 2799-2808.
Ko L. , Prives C. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 1996; 10:243851. Chene P. The role of tetramerization in p53 function. Oncogene 2001; 20:2611-7. Cherny D. , Jett S. , Jovin T. M. DNA bending due to specific p53 and p53 core domain-DNA interactions visualized by electron microscopy. J Mol Biol 1999; 294:1015-26. 44 Chapter 2 Chipuk J. , Green D. R. Cytoplasmic p53: Bax and Forward. Cell Cycle 2004; 3:429-31.